There are many different databases: from the small and useful SQLite to the powerful Teradata.
Relational Databases are very interesting because they’re based on useful and reusable concepts.
There is a package for connecting to a .NET application (just search .NET MySQL library and it should turn up), with Java you can use Hibernate (or any other ORM Framework) and set the dialect to whichever version of MySQL you’re using in the hibernate.config file. Or you could just use ODBC/JDBC directly. I’m sure other languages have their own support.
Any application, if built well, should be able to be supported by a variety of databases, and it should not affect the application. Switching between databases should involve changing a couple of property files at most, and then testing for database-specific idiosyncrasies.
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